新冠病毒原子图出炉 这将有助于疫苗的研发-看世界

新冠病毒原子图出炉 这将有助于疫苗的研发

新冠病毒原子图出炉!2月19日,美国科学家宣布,他们创建了首个新冠病毒附着并感染人类细胞部分的3D原子尺度结构图。研究小组正在将其分子结构图发送给世界各地的研究者,包括中国的许多团体,这将有助于疫苗的研发。

On February 19, American scientists announced that they had created the first three-dimensional atomic scale structure map of the new coronavirus attaching and infecting human cells. The team is sending its molecular structure map to researchers around the world, including many groups in China, which will help vaccine development.

该模型还可帮助科学家开发新蛋白,结合到刺突的不同部位,阻止其发挥功能,治疗已经被感染的人。

The model can also help scientists develop new proteins that bind to different parts of the spike, prevent it from functioning and treat people who have been infected.

得克萨斯大学奥斯汀分校和美国国立卫生研究院(NIH)的研究小组首先研究了中国研究人员公开提供的病毒遗传密码,并用它来开发了一个病毒刺突蛋白的样本。然后他们使用低温电子显微镜对刺突蛋白进行成像。

A team from the University of Texas at Austin and the National Institutes of Health (NIH) first studied the genetic code of the virus publicly provided by Chinese researchers and used it to develop a sample of the virus's spike protein. They then imaged the spike protein using a low-temperature electron microscope.

研究负责人表示,刺突蛋白是我们想要引入人类的抗原,来引发免疫反应产生抗体。这样一来,当碰到真正的病毒时,免疫系统已经准备好攻击了。

The head of the study said the spike protein is an antigen we want to introduce into humans to trigger an immune response to produce antibodies. This way, the immune system is ready to attack when it comes to a real virus.

此外,该团队还通过冷冻电镜Cryo-EM解析出新冠病毒首个S蛋白的近原子分辨率结构,发现新冠病毒S蛋白三聚体的在多数时候其三个受体结合域(Receptor-binding domains,RBDs)中的一个发生了旋转,使得其更容易与细胞表面的受体相互作用。这也说明了为何2019-nCoV的传染性较其他冠状病毒传染性更强。

In addition, the team also analyzed the near atomic resolution structure of the first s protein of the new coronavirus by cryo em, and found that most of the three receptor binding domains (RBDS) of the new coronavirus s protein trimer rotated, making it easier to interact with the receptors on the cell surface. This also explains why 2019 ncov is more infectious than other coronaviruses.

据了解,三位开发该技术的科学家曾于2017年被授予诺贝尔化学奖。

It is understood that three scientists who developed the technology were awarded the Nobel Prize for chemistry in 2017.

声明:转载此文是出于传递更多信息之目的。若有来源标注错误或侵犯了您的合法权益,请作者持权属证明与本网联系,我们将及时更正、删除,谢谢。

Disclaimer: This article is reproduced for the purpose of transmitting more information. If there is a source marking error or infringing your legitimate rights and interests, please contact our website with the ownership certificate. We will correct and delete it in time. Thank you.

免责声明:文章来自互联网,不代表本站的观点,如有侵权或不实言论,请第一时间联系删除,谢谢!!

本文由 看世界 作者:小小 发表,其版权均为 看世界 所有,文章内容系作者个人观点,不代表 看世界 对观点赞同或支持。如需转载,请注明文章来源。

发表评论