In the early novel coronavirus outbreak, many experts and scholars said that the virus could mutate. According to the latest findings of the Chinese research team, the new coronavirus has recently produced 149 mutation points and evolved two subtypes, i.e. l subtype and s subtype. Among them, l subtype is more aggressive and infectious.
以上研究来自中国院主办的《国家 评论》(National Science Review)于3月3日发表的论文《关于SARS-CoV-2的起源和持续进化》(On the origin and continuing evolution of SARS-CoV-2)。
The above research comes from the paper on the origin and continuing evolution of sars-cov-2 published by the National Science Review sponsored by the Chinese Academy of Sciences on March 3.
The corresponding authors of this paper are Lu Jian (bioinformatics center, School of life sciences, Peking University), Cui Jie (Shanghai Pasteur Institute, Chinese Academy of Sciences).
Based on the molecular evolution analysis of 103 new coronavirus genomes, we found that there are 149 mutation points in the virus strains, and most of them are produced recently. This study revealed that two subtypes, l and s, have evolved in the new coronavirus. 101 of them belong to these two subtypes. In terms of proportion, l subtype is more common, reaching 70%, and s subtype accounts for 30%.
According to the novel coronavirus evolution, the transmission ability and severity of L subtype and S subtype may be quite different.
According to the paper, the difference between the two subtypes lies in the 28144 site of the RNA genome of the virus. The L subtype is the T base (corresponding to leucine, Leu), and the s subtype is the C base (corresponding to serine, Ser). Compared with other coronaviruses, the authors found that the new S-type coronavirus is more similar to the bat derived coronavirus in the evolutionary tree, and thus concluded that S-type is relatively older.
L-subtype is more common in the early stage of Wuhan outbreak, and the frequency of l-subtype decreased after the beginning of January 2020. The authors believe that human intervention may exert more selective pressure on L subtype, without which l subtype may be more aggressive and spread more rapidly. On the other hand, due to the relatively weak selection pressure, the older and less aggressive S-type may increase in relative frequency. These findings mean that there is an urgent need for further comprehensive research based on genome data, epidemiological data and 2019 clinical symptom chart records of patients with coronavirus disease.
In addition, it should be noted that the 103 samples showed that most patients only infected with one of L or s subtypes. However, a virus strain isolated from an American patient who had recently traveled to Wuhan showed that he may be infected with both L-type and S-type new coronavirus at the same time. However, the authors say that the possibility of new mutants cannot be ruled out.
不久前，巴西的一项研究就显示了新冠病毒突变的可能性。巴西科学家与英国科学家紧密合作，紧急针对在2月26日出现的巴西首例确诊病例进行“冠状病毒基因定序”，并根据他们的发现公开发表论文，论文题为“First report of COVID-19 in South America”。
Not long ago, a Brazilian study showed the possibility of mutations in the new coronavirus. Brazilian scientists worked closely with British scientists to conduct "coronavirus gene sequencing" for the first confirmed case in Brazil on February 26, and published a paper entitled "first report of covid-19 in South America" based on their findings.
结果显示，这名患者体内的新冠病毒“Brazil/SPBR1/2020 ”，居然与武汉公布的病毒基因(Hu-1参考菌株)存在3处不同——也就是说，病毒可能在传播过程中已经发生变异。同时，前者有两处跟德国慕尼黑群聚传染事件中提取的病毒 “德国/BavPat1/2020菌株 ”非常接近。
The results show that the new coronavirus "Brazil / spbr1 / 2020" in this patient is actually different from the virus gene (hu-1 reference strain) published in Wuhan in three places - that is, the virus may have changed in the process of transmission. At the same time, two of the former are very close to the virus "German / bavpat1 / 2020 strain" extracted from the mass infection event in Munich, Germany.
The patient, 61 years old, visited Lombardy in northern Italy from February 9 to 21. The diagnosis was made on February 26.
Disclaimer: This article is reproduced for the purpose of transmitting more information. If there is a source marking error or infringing your legitimate rights and interests, please contact our website with the ownership certificate. We will correct and delete it in time. Thank you.